Mechanism by which pacing rate affects the upper limit of ventricular vulnerability to fibrillation by T-wave stimulation

TitleMechanism by which pacing rate affects the upper limit of ventricular vulnerability to fibrillation by T-wave stimulation
Publication TypeJournal Article
Year of Publication1999
AuthorsMalkin RA, Hoffmeister BK
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
Start Page284-
Date Published01/1999
Abstract

A stimulus in the T-wave of the heart's normal cycle can alter the heart's activity. However, there is an upper limit (ULV) to stimulus strength that can cause conversion to ventricular fibrillation (VF). Since the ULV is correlated with the defibrillation threshold, it might be a safer alternative or adjunct to clinical defibrillation efficacy testing and may give insights into defibrillation mechanisms. This work demonstrates that the ULV is sensitive to the number and rate of proceeding paced beats. Possible mechanisms for this dependence are presented, perhaps giving insights into defibrillation.

Short TitleAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings