Statistical analysis of signals from an intracavitary probe in a diseased heart.

TitleStatistical analysis of signals from an intracavitary probe in a diseased heart.
Publication TypeJournal Article
Year of Publication1997
AuthorsMalkin RA, Penzotti JE, Juhlin SP, Pilkington TC, Plonsey R
JournalMedical & Biological Engineering & Computing
Start Page462
Pagination462 - 466
Date Published09/1997

A model study introduces the use of statistical signal processing to analyse the signals from an intracavitary probe. A complete derivation is given for the detection of one type of arrhythmogenic substrate, myocardial infarctions (MIs). Both the use of statistical signal processing and the detection of VT substrates, as opposed to activation maps, are unique. A quasi-stationary electromagnetic model with simplified geometry is presented. The model is used to simulate ventricular pacing in the presence of MI. The likelihood ratio is used for detection. A tabulation of the results from this model shows that an intracavitary probe can be used to detect MIs as small as 400 mm2 in 1 mV of noise with a detectability index of 0.495, where 0.5 indicates perfect detection. Sensitivity to noise can be reduced by analysing multiple heart beats. The results are only slightly affected by changing the probe from a cage frame design, which mechanically supports the electrodes on thin spokes, to a balloon design, which supports the electrodes on the surface of an insulating balloon.

Short TitleMedical & Biological Engineering & Computing