Extended cardiac tachyarrhythmias in guinea pigs

TitleExtended cardiac tachyarrhythmias in guinea pigs
Publication TypeJournal Article
Year of Publication1997
AuthorsMalkin RA, Eynard J-N, Pergola NF
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
Start Page387
Pagination387 - 388
Date Published01/1997
Abstract

Guinea pigs are frequently used as models for ventricular tachyarrhythmias, including polymorphic ventricular tachycardia and ventricular fibrillation. However, applications of the model for the development of new cardioversion and defibrillation technology are limited because the arrhythmias typically last less than five seconds. This study demonstrates that a brief period of rapid pacing facilitates the initiation of consistent, sustained ventricular tachyarrhythmias in large guinea pigs, eliminating spontaneous termination as a confounding factor in the study of acute therapies.

Short TitleAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings